منابع مشابه
Changes in human red blood cells during aging in vivo.
The human red blood cells survive in the circulation for 120 days. Density-gradient centrifugation technique is widely used to prepare red cell fractions of different ages. It has been known that various biochemical properties of the red cells change with aging in vivo. If the changes in the red cell surface lead to the destruction of senescent cells, it would be of interest to know how these c...
متن کاملSub-acute Exposure to Benzene Accelerates the Aging Process of Red Blood Cells; an In vivo Study
Background: The well-known toxic effects of benzene toxicity are bone marrow depression, reduction in blood cell counts, and induction of leukemia and aplastic anemia. This study was designed to evaluate biomarkers of aging in red blood cells (RBCs). Methods: Mice were exposed to benzene (50, 100, and 200 mg/kg/day) orally for 28 days. A group of benzene-exposed mice were injected intraperiton...
متن کاملRed Cell Aging . I . Surface Charge
It has been suggested that decreases in red cell surface-charge density accompany aging in vivo and reflect alterations in the cell surface which play a critical role in the recognition and elimination of effete erythrocytes by macrophages in the reticuloendothelial system. The bases for this suggestion are reports that the surfacecharge density progressively decreases for red cell subpopulatio...
متن کاملMeasurement of red cell lifespan and aging.
SUMMARY The measurement of red blood cell (RBC) survival has a long history, and a wide variety of methods have been utilized for this purpose. Current methods are of 2 types. First, those that label a representative sample of RBCs of all ages from the blood and then measure their rate of disappearance upon reinfusion. This category includes the (51)Cr and biotin labels. Second, those that use ...
متن کاملPhosphatidylserine exposure and red cell viability in red cell aging and in hemolytic anemia.
Phosphatidylserine (PS) normally localizes to the inner leaflet of cell membranes but becomes exposed in abnormal or apoptotic cells, signaling macrophages to ingest them. Along similar lines, it seemed possible that the removal of red cells from circulation because of normal aging or in hemolytic anemias might be triggered by PS exposure. To investigate the role of PS exposure in normal red ce...
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ژورنال
عنوان ژورنال: Journal of Clinical Investigation
سال: 1971
ISSN: 0021-9738
DOI: 10.1172/jci106619